Anti Xa Reversal / Adverse Effects and Dangers of Florquinolone use

Activity Details
  • Credit Amounts:
    • CME: 1.00
    • CPE: 1.00
  • Cost: Free
  • Release: May 8, 2019
  • Expires: May 7, 2022
  • Estimated Time to Complete:
    1 Hour(s)
  • Average User Rating:
    (2 Ratings)


Megan N.  Ballard Megan N. Ballard, PharmD
PGY1 Pharmacy Resident
Ephraim McDowell Regional Medical Center
Danville, Kentucky

Kathleen Martello Kathleen Martello, PharmD
PGY1 Pharmacy Resident
Ephraim McDowell Regional Medical Center
Danville, Kentucky

Needs Statement

Fluoroquinolones are one of the most commonly prescribed antibiotics for infections such as pneumonia and urinary tract infections, however, this drug class carries several serious warnings and adverse effects affecting both the inpatient and outpatient population.

New data has been published in recent months and years regarding reversal of anti-Xa agents, and generalist are unable to keep up with details of literature & new research and data related to adverse effects of fluoroquinolones.

Target Audience

Physicians, Nurse Practitioners, Pharmacists, Residents and Technicians


At the completion of this activity, the participant will be able to:
1. Describe the appropriate preparation techniques for Anti-Xa reversal agents
2. Evaluate the current literature for anti-Xa reversal agents
3. Discuss dosing recommendations of anti-Xa reversal agents
4. Review literature and new FDA warnings related to the dangers and adverse effects of FQs
5. Identify patients pre-disposed to adverse effects associated with FQ use
6. Discuss impact on practice, prescribing, and therapeutic recommendations


This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the University of Kentucky College of Medicine, and Ephraim McDowell Regional Medical Center. The University of Kentucky College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

The University of Kentucky College of Medicine designates this enduring material for a maximum of 1.00 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The University of Kentucky College of Medicine presents this activity for educational purposes only. Participants are expected to utilize their own expertise and judgment while engaged in the practice of medicine. The content of the presentations is provided solely by presenters who have been selected for presentations because of recognized expertise in their field.

ACGME Competencies

  • Patient care
  • Medical knowledge
  • Practice-based learning and improvement
  • Systems-based practice

ACPEThe University of Kentucky College of Pharmacy is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education.

This knowledge-based activity has been assigned UAN 0022-9999-19-089-H01-P and will award 1.00 contact hour (0.100 CEUs) of continuing pharmacy education credit in states that recognize ACPE providers.

Statements of participation will indicate hours and CEUs based on participation and will be issued online at the conclusion of the activity. Successful completion includes completing the activity, its accompanying evaluation and/or posttest (score 70% or higher) and requesting credit online at the conclusion of the activity. Credit will be uploaded to CPE Monitor, and participants may print a statement of credit or transcript from their NABP e-profile. The College complies with the Accreditation Standards for Continuing Pharmacy Education.

Faculty Disclosure

No speakers have any relevant financial relationships to disclose.

The material presented in this course represents information obtained from the scientific literature as well as the clinical experiences of the speakers. In some cases, the presentations might include discussion of investigational agents and/or off-label indications for various agents used in clinical practice. Speakers will inform the audience when they are discussing investigational and/or off-label uses.

Disclosure of a relationship is not intended to suggest or condone commercial bias in any presentation, but it is made to provide participants with information that might be of potential importance to their evaluation of a presentation.


This activity is jointly provided by the University of Kentucky and Ephraim McDowell Regional Medical Center.